![]() However, the efficacy of heparin prophylaxis in COVID-19 patients, as determined by laboratory data, and the factors affecting this efficacy are not known. ![]() Previous studies have shown that heparin prophylaxis reduces thromboembolic events in COVID-19 patients. However, the dose that can be used has not been clarified. The International Society on Thrombosis and Hemostasis (ISTH), American Society of Hematology (ASH), and American College of Cardiology (ACC) recommend heparin prophylaxis in patients with COVID-19. Eosinophil levels are clinically important because they are potent pro-inflammatory cells containing cytotoxic proteins and various enzymes (peroxidases, cationic proteins, and neurotoxins) that can influence the effectiveness of heparin. Įosinophils normally make up only a small fraction of circulating leukocytes (1–3%), but their levels can vary in different disease states. Several studies have indicated an increase in some hematologic parameters that may lead to endothelial damage, immobilization-related stasis, and hypercoagulability. The cause of the hypercoagulation in COVID-19 patients has not been fully understood. Several reports have shown that, similar to other viral pneumonia, the incidence rate of venous thromboembolism (VTE) in COVID-19 patients, particularly those in intensive care, is high. Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which has been considered a pandemic by the World Health Organization (WHO). The clinical significance of the subprophylactic anti-factor Xa activity should be studied in COVID-19 patients (NCT04507282). In conclusion Elevated eosinophil count is related to lower anti-factor Xa activity in patients with COVID-19 receiving LMWH. ROC analysis for the presence of anticoagulation at subprophylactic level revealed an area under curve of 0.79 (95% CI: 0.64–0.93) p = 0.001). Anti-factor Xa activity in blood, drawn 4 h after the 3rd dose of LMWH, was measured and an activity of 4%, 6 were in group 1 ((6/13) 46.2%), while 8 were in group 2 ((8/63) 11.9%) ( p = 0.009), and all had a D-dimer level < 1 μg/mL ( p = 0.03). We prospectively evaluated 80 COVID-19 patients, diagnosed using polymerase chain reaction test, who were admitted to our clinic and administered LMWH LMWH (enoxaparin) was applied according to the weight, D-dimer levels, and clinical condition of patients. This study aimed to evaluate the factors influencing anti-factor Xa activity in COVID-19 patients receiving low molecular weight heparin (LMWH). Despite prophylactic anticoagulant treatments, thrombotic complications may develop in patients with coronavirus disease 2019 (COVID-19).
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